AcL1

AcL1 is an acetogenin-rich fraction derived from the ethyl acetate extract of *Annona coriacea* Mart., a plant native to the Brazilian Cerrado. It has demonstrated potent and selective cytotoxicity against human glioblastoma (GBM) cell lines, such as U87MG and A172, outperforming the standard chemotherapy temozolomide in preclinical models. The mechanism of action for AcL1 involves the induction of necroptosis, a form of programmed cell death characterized by the upregulation of receptor-interacting protein kinases 1 and 3 (RIPK1 and RIPK3) and apoptosis-inducing factor (AIF), notably without the activation of cleaved caspase 8. Furthermore, AcL1 has been shown to inhibit tumor cell migration and reduce the activity of matrix metalloproteinase-2 (MMP-2), suggesting its potential to limit the invasive capacity of glioblastoma cells.

Other names

Annona coriacea ethyl acetate fraction 1Acetogenin-rich fraction AcL1