Drug intelligence / Profile preview

ACM-001

Development stage
Unknown
Lead developer
Actimed Therapeutics
Modality
MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration
Intramuscular, Mucosal
01

Overview

ACM-001 is an investigational **adjuvanted protein-subunit booster vaccine for COVID-19** developed by ACM Biolabs. The vaccine contains a SARS-CoV-2 spike-protein antigen modeled on the Beta variant and the immunostimulatory CpG 7909 adjuvant, formulated with ACM Biolabs' polymer-based Tunable Platform delivery technology. It was evaluated as a single booster dose by intramuscular and intranasal administration in a completed Phase 1 study in previously vaccinated healthy adults. ACM Biolabs reported that the Phase 1 study showed acceptable tolerability, no serious adverse events at recommended dose levels, and early evidence of broadly reactive antibody responses. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05385991))

Other names
ACM-SARS-CoV-2-beta ACM-CpG vaccine candidateACM-SARS-CoV2-beta ACM-CpG vaccine candidateACM-SARS-CoV 2-beta ACM-CpG vaccine candidateACM-SARS-CoV-2-beta ACM-CpG vaccineACM-SARS-CoV2-beta ACM-CpG vaccineACM-SARS-CoV 2-beta ACM-CpG vaccine
02

Targets

SARS-CoV-2 spike

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