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Aconit Schmerzöl
- Development stage
- Unknown
- Lead developer
- WALA Heilmittel
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Aconit Schmerzöl is an anthroposophic medicinal product developed by WALA Heilmittel GmbH, primarily used for the topical treatment of painful conditions affecting the nervous and musculoskeletal systems. The formulation contains a combination of Aconitum napellus (monkshood) extract, camphor, lavender oil, and rosemary oil in a peanut oil base. Its mechanism of action is multi-faceted: Aconitum alkaloids (such as aconitine) modulate voltage-gated sodium channels to provide local analgesia, while camphor acts on various transient receptor potential (TRP) channels to induce a warming sensation and further alleviate pain. Lavender and rosemary oils contribute to the product's soothing and circulation-enhancing properties. While traditionally used for neuralgia, sciatica, and joint pain, Aconit Schmerzöl has gained clinical attention for its potential in managing chemotherapy-induced peripheral neuropathy (CIPN), where it is being evaluated in Phase 2 clinical trials.
- Brand names
- Aconit Schmerzöl
- Other names
- Aconite Pain Oil
02
Targets
TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV3 (Transient receptor potential vanilloid subtype 3)NaV (Voltage-gated sodium channels)
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