Drug intelligence / Profile preview

aconiti lateralis radix praeparata

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

**Aconiti Lateralis Radix Praeparata** (熟附子, Fuzi) is the processed lateral root of *Aconitum carmichaelii* Debx., widely used in traditional Chinese medicine (TCM). It is known for its strong actions to restore yang from collapse, reinforce fire and strengthen yang, dispel cold to alleviate pain, and unblock meridians. The herb is indicated for conditions such as cold limbs, arthralgia (joint pain), impotence, edema, loose stool or constipation due to yang deficiency or cold accumulation. It must be carefully processed before use to reduce toxicity; improper processing or dosage can lead to severe adverse effects[1][2][3].\n\n**Mechanism of Action:** The main active compounds are diester-diterpenoid alkaloids such as aconitine, mesaconitine, and hypaconitine. These compounds have been shown in modern studies to possess anti-inflammatory and analgesic properties. Processing transforms highly toxic diester-diterpenoid alkaloids into less toxic monoester or non-esterified forms[2][4][9]. The herb acts by warming the body’s interior channels (meridians), invigorating heart and kidney yang energy, dispersing coldness from the body’s interior and channels.

Other names
熟附子FuziPrepared Aconite RootPrepared AconiteChinese WolfsbanePrepared Daughter Root of Common Monk's Hood
02

Targets

SCN10A (Sodium channel protein type X alpha subunit)

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