Drug intelligence / Profile preview

acorus calamus volatile oil

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Topical, Inhalation
01

Overview

Acorus calamus volatile oil is a complex essential oil extracted primarily from the rhizomes of the *Acorus calamus* plant, commonly known as sweet flag. It is characterized by its high concentration of phenylpropanoids, most notably **beta-asarone** and **alpha-asarone**, which are responsible for its broad pharmacological profile. The oil exhibits significant neuroprotective, sedative, and anticonvulsant properties, primarily through the modulation of the GABAergic system and the inhibition of acetylcholinesterase. Historically used in Ayurvedic and Traditional Chinese Medicine for cognitive enhancement and gastrointestinal disorders, modern research has focused on its potential in treating epilepsy and neurodegenerative diseases. However, its clinical development is strictly regulated in many regions, including the United States, due to the proven mutagenic and carcinogenic potential of the beta-asarone constituent, leading to the use of 'asarone-free' varieties for consumption.

Other names
calamus oilsweet flag oilacori calami aetheroleumcalamus essential oiloil of sweet flag
02

Targets

GABRR (GABA-A receptor subunit rho)

Beyond the preview

Go deeper on acorus calamus volatile oil.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on acorus calamus volatile oil.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call