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acorus gramineus extract
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Acorus gramineus extract is a botanical extract derived from the rhizome of the *Acorus gramineus* Solander plant, commonly known as grass-leaved sweet flag. Traditionally used in Asian medicine for central nervous system (CNS) disorders, the extract is being investigated for its anti-neuroinflammatory and neuroprotective effects, particularly in the context of Parkinson's disease. Its mechanism of action involves the inhibition of pro-inflammatory mediators, including nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta), by modulating the NF-kappaB, MAPK, and TRIF-dependent signaling pathways in activated microglia. Preclinical studies in MPTP-induced mouse models suggest it can prevent neuronal cell death and mitigate neuroinflammation.
- Other names
- Acorus gramineus Solander extractAG extractGrass-leaved sweet flag extract
02
Targets
ALOX12 (Arachidonate 12-lipoxygenase, 12S type)
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