activated autologous lymphocyte therapy

Activated autologous lymphocyte therapy is an adoptive cell immunotherapy that involves the collection of a patient's own lymphocytes via apheresis, followed by ex vivo activation and expansion, and subsequent re-infusion. In the context of high-grade gliomas, it is used as an adjunct to standard-of-care treatments like the Stupp regimen (surgery, radiotherapy, and temozolomide). The therapy aims to induce tumor-specific immunity and counteract the lymphopenia often induced by cytotoxic chemotherapy, thereby potentially improving progression-free and overall survival.

Other names

activated autologous lymphocytesautologous activated lymphocyte therapy