ActRIIB-mFc

ActRIIB-mFc is a preclinical **recombinant activin type IIB receptor Fc fusion protein** that functions as a soluble ligand trap for members of the TGF-beta superfamily, especially ligands that signal through activin receptor type IIB such as **myostatin** and **activin A**. In the provided Duchenne muscular dystrophy mdx mouse study, it was used as a mouse Fc-containing comparator to engineered follistatin and produced increases in body weight and skeletal muscle mass with some reductions in fibrosis and inflammation markers, but generally showed less favorable pathology-associated gene-expression effects than FS-EEE-mFc. The context identifies it as a research/preclinical biologic comparator rather than a marketed or clinically established therapeutic product, and no INN or brand name is provided in the source excerpt.

Other names

recombinant activin type IIB receptor Fc fusionactivin RIIB Fc chimera proteinActRIIB-Fc