Drug intelligence / Profile preview

ACUVUE Theravision with Ketotifen

Development stage
Unknown
Lead developer
Johnson & Johnson
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

ACUVUE Theravision with Ketotifen is a daily wear, daily disposable **etafilcon A drug-eluting contact lens** which delivers **ketotifen**, a selective H1 histamine receptor antagonist and mast cell stabilizer, directly to the ocular surface[1][3][4][5]. It is used for the **prevention of ocular itch due to allergic conjunctivitis** and simultaneous correction of refractive ametropia (myopia and hyperopia) in suitable patients[1][2][3][4][5]. The lens gradually releases a low dose of ketotifen (19 mcg/lens) to provide up to 12 hours of anti-allergy effect[1][2][3][4][5]. The product creates a new modality where vision correction and allergy medication are combined into one device. Developed and manufactured by Johnson & Johnson Vision Care, it is the first and only FDA-approved drug-eluting contact lens in its class[5]. The primary mechanism of action is via antagonism of the H1 histamine receptor in the eye, providing both **antihistaminic and mast cell stabilizing effects**[3][4]. Indicated for patients without red eye(s), suitable for contact lens wear, and with no more than 1.00 diopter of astigmatism[1][2].

Brand names
ACUVUE Theravision with Ketotifen
Other names
ACUVUE TheravisionACUVUE Theravision + ketotifen
02

Targets

HRH1 (Histamine H1 Receptor)

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