Drug intelligence / Profile preview

ACYW135 Meningococcal Polysaccharide Vaccine

Development stage
Phase 3
Lead developer
CanSino Biologics
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular, Subcutaneous
01

Overview

The ACYW135 Meningococcal Polysaccharide Vaccine is a quadrivalent vaccine designed to provide active immunization against invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A, C, Y, and W135. The vaccine contains purified capsular polysaccharides from each of these four serogroups. Unlike conjugate vaccines, these polysaccharides are not chemically linked to a carrier protein, making them effective primarily in older children and adults by stimulating the production of group-specific bactericidal antibodies. Several major Chinese biopharmaceutical companies, including Walvax Biotechnology, Hualan Biological Engineering, and Zhifei Lvzhu, have developed versions of this vaccine, which are frequently used as active controls in clinical trials for newer conjugate formulations.

Other names
ACYW135多糖疫苗Group ACYW135 Meningococcal Polysaccharide VaccineQuadrivalent Meningococcal Polysaccharide VaccineMenACYW Polysaccharide Vaccine
02

Targets

Neisseria meningitidis group C capsular polysaccharideNmA CPS (Neisseria meningitidis group A capsular polysaccharide)MenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)

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