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AD-303
- Development stage
- Unknown
- Lead developer
- Moogene Medi
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
AD-303 (also known as HUTERA D) is a topical lipid nanoparticle (LNP) formulation of the 5-alpha reductase inhibitor dutasteride, being developed for the treatment of androgenetic alopecia (male pattern hair loss). Developed by Moogene Medi in collaboration with Addpharma, Yuhan, JW Shinyak, Medica Korea, and Chong Kun Dang, AD-303 utilizes Moogene Medi's proprietary LNP drug delivery system to effectively deliver dutasteride directly to hair follicles and scalp tissues. This localized delivery is designed to selectively lower dihydrotestosterone (DHT) levels in the scalp while minimizing systemic exposure and the associated side effects of oral dutasteride, such as sexual dysfunction and liver toxicity. The candidate is currently in Phase 1/2a clinical development in South Korea.
- Brand names
- HuteraHutera D
- Other names
- dutasteride topicaltopical dutasteride
02
Targets
SRD5A1 (Steroid 5-alpha-reductase type 1)SRD5A2 (Steroid 5-alpha-reductase type II)
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