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Ad-DLMP1-LMP2 DC vaccine
- Development stage
- Unknown
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Gene Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
The Ad-ΔLMP1-LMP2 DC vaccine is an experimental autologous dendritic cell (DC) immunotherapy designed to treat Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC). The vaccine consists of a patient's own dendritic cells that have been genetically modified using a recombinant adenovirus vector to express two specific EBV antigens: a truncated version of Latent Membrane Protein 1 (ΔLMP1) and the full-length Latent Membrane Protein 2 (LMP2). By presenting these viral antigens, the vaccine aims to stimulate a T cell-mediated immune response against NPC cells that express these proteins. Clinical evaluation in Phase II studies has demonstrated safety and the induction of delayed-type hypersensitivity responses, although clinical efficacy in advanced metastatic disease remains a focus for further optimization.
- Other names
- Ad-ΔLMP1-LMP2 DC vaccineAd-DLMP1-LMP2 transduced DC vaccineAd-DLMP-1-LMP2 transduced DC vaccineAd-DLMP 1-LMP2 transduced DC vaccine
02
Targets
LMP1 (Epstein-Barr virus latent membrane protein 1)Epstein-Barr virus latent membrane protein 1/2-specific T-cell receptorPSMB9 (Immunoproteasome subunit beta type-1i)
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