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Ad-Foxj2
- Development stage
- Preclinical
- Modality
- Gene Therapies
- Administration
- Injection
01
Overview
Ad-Foxj2 is a recombinant adenoviral vector engineered to deliver and overexpress the Forkhead box J2 (Foxj2) transcription factor. Foxj2 is a member of the forkhead/hepatocyte nuclear factor 3 family, which plays a critical role in various biological processes, including the regulation of the innate immune response and cellular homeostasis. Preclinical research indicates that Ad-Foxj2 can attenuate lipopolysaccharide (LPS)-induced inflammatory responses in macrophages, suggesting a potential therapeutic role in managing inflammatory diseases. By increasing Foxj2 levels, the vector modulates downstream signaling pathways that govern cytokine production and macrophage activation, thereby dampening excessive inflammatory signaling.
- Other names
- Adenovirus-Foxj2Adenovirus-Foxj-2Adenovirus-Foxj 2Ad-FOXJ2Ad-FOXJ-2Ad-FOXJ 2Adenoviral Foxj2
02
Targets
FOXJ2 (Forkhead box protein J2)
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