Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Ad-MCP1-tk
- Development stage
- Preclinical
- Lead developer
- Kanazawa University
- Modality
- Gene Therapies
- Administration
- Intratumoral
01
Overview
**Ad-MCP1-tk** is an experimental bicistronic recombinant adenoviral cancer gene-therapy vector designed for hepatocellular carcinoma. It expresses **monocyte chemoattractant protein-1** and **herpes simplex virus thymidine kinase** from a CAG promoter through an internal ribosomal entry site, with MCP-1 positioned upstream of HSV-tk. HSV-tk sensitizes transduced tumor cells to ganciclovir-mediated cytotoxicity, while MCP-1 promotes macrophage recruitment and macrophage-associated tumor necrosis factor-alpha production. In preclinical hepatocellular carcinoma models, Ad-MCP1-tk was less effective at suppressing tumor growth than the reverse-order vector Ad-tk-MCP1.
- Other names
- AD-MCP1-TKAD-MCP-1-TKAD-MCP 1-TKrecombinant adenovirus vector expressing monocyte chemoattractant protein-1 and herpes simplex virus thymidine kinase
02
Targets
HSV-TK (Herpes simplex virus type 1 thymidine kinase (HSV1-TK))
Beyond the preview
Go deeper on Ad-MCP1-tk.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ad-MCP1-tk.