Ad-MMP-2-Si

Ad-MMP-2-Si is an adenoviral vector-based gene therapy designed to deliver small interfering RNA (siRNA) targeting matrix metalloproteinase-2 (MMP-2). MMP-2, also known as gelatinase A, is a zinc-dependent endopeptidase involved in the degradation of the extracellular matrix, which is a critical step in tumor invasion and metastasis. In glioblastoma models, Ad-MMP-2-Si has been shown to downregulate MMP-2 expression, leading to the inhibition of cell migration and invasion. This effect is mediated through the disruption of the MMP-2/integrin αVβ3/FAK signaling complex, which subsequently reduces the activation of Rho GTPases Rac1 and Cdc42. The therapy was primarily investigated in preclinical settings for the treatment of malignant gliomas.

Other names

Ad-MMP-2-siRNAAd-MMP2-siRNAAd-MMP 2-siRNAadenoviral vector expressing MMP-2 siRNA