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Ad-p16
- Development stage
- Unknown
- Lead developer
- Shanghai Sunway Biotech
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Gene Therapies
- Administration
- Intratumoral, Intra-arterial
01
Overview
Ad-p16 is an investigational gene therapy in which an adenoviral vector (Ad) delivers the human p16 gene to target cells, aiming to restore or enhance expression of p16, a cyclin-dependent kinase inhibitor with tumor suppressor activity. The p16 protein slows cell division by inhibiting cell cycle progression from G1 to S phase, making it a critical regulator of cellular senescence and a tumor suppressor implicated in a range of cancers. Ad-p16 is primarily being studied for cancers where CDKN2A (the gene encoding p16) is inactivated or its product is deficient, with the intended mechanism to restore the tumor-suppressive cell cycle arrest in malignant cells[1][3][5].
- Other names
- Ad-p16Ad-p-16Ad-p 16
02
Targets
CDK6 (Cyclin-dependent kinase 6)CDK4 (Cyclin-dependent kinase 4)
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