Ad.hIFN-β

Ad.hIFN-β is a recombinant, replication-defective adenoviral gene therapy vector encoding human interferon-β (hIFN-β). After local administration into tumors or serosal cavities, transduced cells express hIFN-β, producing antiproliferative, pro-apoptotic, and immunomodulatory effects, including induction of tumor cell apoptosis and stimulation of innate immune responses such as NK cell activity. Clinical phase 1 studies have evaluated intratumoral administration in malignant glioma and intrapleural administration in pleural malignancies, demonstrating detectable intratumoral hIFN-β, dose-dependent vector DNA distribution, feasibility, and a safety profile with occasional dose-limiting neurotoxicity at higher intratumoral doses.

Other names

adenoviral interferon-betaadenoviral vector encoding human interferon-betaIFN-β gene therapy vector