Ad.scIL-12

Ad.scIL-12 is an **adenoviral vector** engineered to express a **single-chain form of murine interleukin-12 (IL-12)** as a secreted protein. It is used in preclinical studies for cancer immunotherapy. By delivering the gene encoding IL-12 directly into tumor cells via an adenovirus, Ad.scIL-12 locally induces robust immune activation—including the generation of tumor-specific cytotoxic T lymphocytes, activation of natural killer (NK) cells, and production of interferon-gamma (IFN-γ)—while aiming to reduce systemic toxicity associated with recombinant IL-12 protein therapy. Its primary research indication is in cancer, notably in murine models of solid tumors, where it has demonstrated strong anti-tumor efficacy upon intratumoral injection[1].

Other names

Ad.scIL-12