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Ad26.RSV.preF + RSV preF protein
- Development stage
- Unknown
- Lead developer
- Janssen Pharmaceutical
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies, Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Ad26.RSV.preF + RSV preF protein is a combination vaccine developed for the prevention of respiratory syncytial virus (RSV) infection, particularly in older adults. The vaccine consists of two components: a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a prefusion conformation-stabilized RSV fusion (preF) protein, and recombinant RSV preF protein. This combination is designed to induce robust humoral and cellular immune responses by presenting the immune system with both vector-expressed and directly administered prefusion F antigen. Clinical studies have demonstrated that this vaccine regimen provides high protective efficacy against lower respiratory tract disease caused by RSV in adults aged 60 years or older[1][2][3][4][5][6]. The addition of the recombinant RSV preF protein enhances immunogenicity compared to either component alone[2]. Janssen, part of Johnson & Johnson, is the primary developer.
- Other names
- Ad26.RSV.preF-RSV preF protein vaccineAd-26.RSV.preF-RSV preF protein vaccineAd 26.RSV.preF-RSV preF protein vaccine
02
Targets
RSV F (Respiratory syncytial virus fusion protein)
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