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Ad4-mgag
- Development stage
- Phase 1
- Lead developer
- Emergent BioSolutions
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies, Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Oral
01
Overview
Ad4-mgag is an investigational oral HIV vaccine candidate that uses a live, replication-competent adenovirus type 4 (Ad4) vector to deliver a mosaic HIV Gag antigen. The vaccine is designed to stimulate both humoral and cellular immune responses against HIV by presenting the Gag protein in a form that mimics natural infection. It has been evaluated in early-phase clinical trials for safety and immunogenicity in healthy, HIV-uninfected adults. The vaccine is administered orally via enteric-coated capsules or as an aqueous formulation[1][2][8]. Developed by Emergent BioSolutions, the approach leverages the ability of adenoviral vectors to induce strong mucosal and systemic immunity.
- Other names
- Ad4-mGagAd-4-mGagAd 4-mGagAdenovirus type-4 mosaic Gag vaccine
02
Targets
Gag (HIV-1 Gag polyprotein)
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