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AD401
- Development stage
- Preclinical
- Lead developer
- Shenzhen Zero-One Life Technology
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Topical
01
Overview
AD401 is an engineered bacterial therapeutic developed by Shenzhen 01 Life Technology (01Life) for the topical treatment of atopic dermatitis. As a microbiome-based therapy, it utilizes engineered bacteria to modulate the skin's microbial environment and alleviate symptoms associated with atopic dermatitis. The drug is currently in the IND-enabling stage of development, representing a novel approach to dermatological conditions by leveraging synthetic biology to create live biotherapeutic products.
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