AD5-10

AD5-10 is a monoclonal agonistic antibody targeting the tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2), also known as Death Receptor 5 (DR5). By binding to DR5, AD5-10 mimics the action of the natural ligand TRAIL, triggering the extrinsic apoptotic pathway specifically in cancer cells. Research indicates that AD5-10 can resensitize ovarian cancer cells to TRAIL-mediated and NK-cell-mediated apoptosis, and exhibits synergistic effects when combined with chemotherapy agents like carboplatin. It has been primarily studied in the context of overcoming TRAIL resistance in ovarian cancer.

Other names

anti-DR5 antibodyanti-DR-5 antibodyanti-DR 5 antibodyDR5 agonistic antibodyDR-5 agonistic antibodyDR 5 agonistic antibody