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Drug intelligence / Profile preview
Ad5-105K
- Development stage
- Phase 1
- Lead developer
- CanSino Biologics
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Inhalation
01
Overview
Ad5-105K is a nebulized recombinant replication-deficient adenovirus serotype 5 (Ad5)-based vaccine being developed by CanSino Biologics. It utilizes an Ad5 vector platform to deliver genetic material encoding a target antigen, stimulating an immune response. The vaccine is designed for respiratory administration via nebulization and is currently in early-phase clinical trials to evaluate its safety and immunogenicity in healthy adults. The primary mechanism involves the delivery of antigenic genes using the Ad5 vector, which induces both innate and adaptive immune responses through activation of antigen-presenting cells and stimulation of cytotoxic T lymphocytes[1][2].
- Other names
- Ad5-105K Inhaled TB VaccineAd-5-105K Inhaled TB VaccineAd 5-105K Inhaled TB VaccineTuberculosis (TB) vaccine (Ad5-105K)
02
Targets
HSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))
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