Ad5-CMV-mTNFa

Ad5-CMV-mTNFa is a replication-deficient adenoviral vector (serotype 5) designed to deliver the murine tumor necrosis factor-alpha (mTNF-α) gene under the control of the constitutive cytomegalovirus (CMV) promoter. TNF-α is a potent cytokine that induces apoptosis in cancer cells, activates the vascular endothelium, and stimulates the immune system. By utilizing an adenoviral vector, researchers can achieve high levels of localized TNF-α expression within the tumor microenvironment, which aims to maximize anti-tumor efficacy while minimizing the systemic toxicity typically associated with recombinant TNF-α protein administration. This construct is primarily used as a research tool in preclinical oncology to study the effects of localized cytokine therapy and its synergy with other modalities such as radiotherapy or chemotherapy in syngeneic mouse models.

Other names

Adenoviral mouse TNF-alphaAd-mTNF-alpha