Ad5luc1

Ad5luc1 is a replication-deficient adenoviral vector based on the human adenovirus serotype 5 (Ad5) platform. It is characterized by a deletion in the E1 region of the viral genome, which prevents it from replicating in non-complementing cell lines, and the inclusion of a luciferase reporter gene, typically driven by a Cytomegalovirus (CMV) promoter. In oncology and gene therapy research, Ad5luc1 is primarily utilized as a negative control for oncolytic (replication-competent) adenoviruses. It allows researchers to distinguish between biological effects resulting from initial viral transduction and transgene expression versus those caused by active viral replication and subsequent oncolysis. The vector utilizes the Coxsackievirus and Adenovirus Receptor (CAR) for cellular entry via its wild-type fiber protein.

Other names

Ad5-CMV-lucAd-5-CMV-lucAd 5-CMV-lucAd5-lucAd-5-lucAd 5-luc