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adalimumab + hydroxychloroquine + leflunomide + methotrexate
- Development stage
- Preclinical
- Lead developer
- AbbVie
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Subcutaneous, Intramuscular
01
Overview
This is a combination therapy used for rheumatoid arthritis (RA) that includes a biologic DMARD (adalimumab) and three conventional DMARDs (hydroxychloroquine, leflunomide, and methotrexate). This combination aims to control disease activity, reduce joint damage, and improve symptoms in patients with rheumatoid arthritis. Methotrexate serves as the anchor drug in this combination, with adalimumab (a TNF inhibitor) providing additional anti-inflammatory effects, while hydroxychloroquine and leflunomide work through different mechanisms to further suppress disease activity.
02
Targets
DHFR (Dihydrofolate reductase)TLR7 (Toll-like receptor 7)DHODH (Dihydroorotate dehydrogenase (quinone), mitochondrial)TNFA (Tumor necrosis factor alpha (soluble))
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