Drug intelligence / Profile preview

adalimumab-adaz

Development stage
Approved
Lead developer
Sandoz
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Subcutaneous
01

Overview

Adalimumab-adaz is a tumor necrosis factor (TNF) blocker and a biosimilar to the reference biologic Humira (adalimumab). It is a recombinant human IgG1 monoclonal antibody that binds with high affinity and specificity to soluble and transmembrane TNF-alpha, but not to TNF-beta (lymphotoxin). By neutralizing TNF-alpha, it inhibits the inflammatory cascade and the production of other pro-inflammatory cytokines and adhesion molecules. Originally developed by Sandoz as GP2017, it is commercialized in the United States through a partnership with Cordavis (a CVS Health company). It is approved for the treatment of various autoimmune and inflammatory conditions, including rheumatoid arthritis, Crohn's disease, ulcerative colitis, and plaque psoriasis. The product is available in high-concentration, citrate-free formulations designed to reduce injection-site pain.

Brand names
HyrimozCordavis Hyrimoz
Other names
adalimumab-adaz
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))

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