Drug intelligence / Profile preview

ADAM

Development stage
Unknown
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules, Hydrogel Systems → Drug Delivery Systems, Device-based Delivery → Drug Delivery Systems
Administration
Vas Deferens Injection, Intravenous
01

Overview

The name "ADAM" is used in the provided context to refer to multiple distinct entities. One such entity is the **ADAM Hydrogel**, a proprietary, injectable, co-polymer hydrogel designed for male contraception. It functions by providing long-lasting, non-permanent occlusion of the vas deferens, preventing sperm transport from the epididymis into the ejaculate. Another distinct entity is **I-123-ADAM**, a selective radioligand used in Single Photon Emission Computed Tomography (SPECT) imaging to evaluate serotonin transporter (SERT) availability, particularly in studies related to depression and breast cancer survivors. The name "ADAM" also appears as an acronym for various clinical trials (e.g., "Amlodipine and Dialysis Patients, Action on Mortality", "ADAM-Afatinib Diarrhea Assessment and Management") and as a protein (ADAM 17, A Disintegrin And Metalloprotease 17).

Other names
ADAM HydrogelADAM SystemI-123-ADAMI123-ADAMI 123-ADAM
02

Targets

SERT (Sodium-dependent serotonin transporter)

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