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adapalene + clindamycin (Lapillus Therapeutics)
- Development stage
- Unknown
- Lead developer
- Lapillus Pharmaceutical
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
AdaLap C Gel is a topical combination therapy developed and marketed by Lapillus Pharmaceutical for the treatment of acne vulgaris. The formulation contains two active ingredients: adapalene (0.1%) and clindamycin phosphate (1.0%). Adapalene is a third-generation topical retinoid that modulates cellular differentiation, keratinization, and inflammatory processes by binding to specific retinoic acid nuclear receptors (RAR-beta and RAR-gamma), thereby reducing comedone formation. Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, providing antimicrobial activity against *Cutibacterium acnes* and exerting anti-inflammatory effects. The product is positioned as a marketed generic/branded OTC dermatology treatment.
- Brand names
- AdaLap C Gel
- Other names
- Adapalene and Clindamycin Phosphate Gel
02
Targets
Bacterial 50S ribosomal subunitRARG (Retinoic acid receptor gamma)RARB (Retinoic acid receptor beta)
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