adapalene + benzoyl peroxide

Adapalene + benzoyl peroxide is a fixed-dose **topical combination** acne therapy composed of adapalene, a third-generation retinoid, and benzoyl peroxide, an oxidizing antimicrobial and keratolytic agent. It is marketed as gels including **Epiduo** and **Epiduo Forte** and is indicated for the topical treatment of **acne vulgaris**. The combination is designed to address complementary pathogenic drivers of acne: adapalene modulates retinoid-responsive pathways that normalize follicular keratinization and reduce inflammatory signaling, while benzoyl peroxide exerts bactericidal activity against *Cutibacterium acnes* and helps reduce comedones and inflammatory lesions. Public sources including FDA labeling, DailyMed listings, and ClinicalTrials.gov records verify the product and its development and marketed use in acne vulgaris.

Brand names

EpiduoEpiduo ForteDifferin Epiduo Acne Gel

Other names

adapalene and benzoyl peroxideadapalene and benzoyl peroxide topical geladapalene-benzoyl peroxideadapalene + benzoyl peroxide