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adapalene + benzoyl peroxide (Actavis Mid-Atlantic)
- Development stage
- Unknown
- Lead developer
- Teva Pharmaceutical
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
A generic topical gel combination of adapalene (0.1%) and benzoyl peroxide (2.5%) developed by Actavis Mid-Atlantic LLC for the treatment of acne vulgaris. Adapalene is a naphthoic acid derivative with retinoid-like activity that binds to specific retinoic acid nuclear receptors (RAR-beta and RAR-gamma), normalizing the differentiation of follicular epithelial cells and resulting in decreased microcomedone formation. Benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects, which releases free radical oxygen species to oxidize bacterial proteins in Cutibacterium acnes. This product was developed as a bioequivalent generic version of Galderma's Epiduo and was involved in a patent settlement in 2015.
- Other names
- adapalene 0.1% and benzoyl peroxide 2.5% topical gelgeneric Epiduo
02
Targets
RARB (Retinoic acid receptor beta)RARG (Retinoic acid receptor gamma)
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