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adapalene + benzoyl peroxide (Laboratório Edol – Produtos Farmacêuticos, S.A.)
- Development stage
- Phase 4
- Lead developer
- Laboratório EDOL Produtos Farmacêuticos
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Aceduo is a topical fixed-dose combination gel containing the third-generation synthetic retinoid adapalene (0.1%) and the oxidizing antimicrobial agent benzoyl peroxide (2.5%). Developed for the treatment of acne vulgaris, Aceduo combines two complementary mechanisms of action to target multiple pathophysiological pathways of acne. Adapalene acts as a selective agonist of nuclear retinoic acid receptors (specifically RAR-beta and RAR-gamma), modulating gene expression to normalize follicular keratinization, promote skin cell turnover, and exert anti-inflammatory effects. Benzoyl peroxide functions as a broad-spectrum antibacterial agent by releasing free oxygen radicals that oxidize bacterial proteins, particularly targeting Cutibacterium acnes, while also providing keratolytic and desquamative properties. This synergistic combination effectively reduces both inflammatory and non-inflammatory acne lesions with a favorable tolerability profile.
- Brand names
- Aceduo
- Other names
- adapalene and benzoyl peroxideadapalene/benzoyl peroxidebenzoyl peroxide and adapalenebenzoyl peroxide/adapalene
02
Targets
FOS (Activator Protein 1)RARB (Retinoic acid receptor beta)RARG (Retinoic acid receptor gamma)RXRA (Retinoid X receptor alpha)TLR2 (Toll-like Receptor 2)
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