ADAPT6-ABD-mcDM1

**ADAPT6-ABD-mcDM1** is an investigational HER2-targeted protein-drug conjugate developed in an academic research setting for HER2-overexpressing cancers. It comprises the engineered HER2-binding ADAPT6 scaffold fused to an albumin-binding domain to extend systemic exposure and conjugated through a maleimidocaproyl linker to the cytotoxic maytansinoid payload mertansine. Following HER2-mediated binding and internalization in tumor cells, the DM1 payload disrupts microtubule function, producing selective cytotoxicity in HER2-high models. It showed antitumor activity in HER2-expressing SKOV3 ovarian cancer xenografts after intravenous administration and remains a preclinical candidate. ([mdpi.com](https://www.mdpi.com/1999-4923/13/11/1847))

Other names

ADAPT6-ABD-mcDM1ADAPT-6-ABD-mcDM1ADAPT 6-ABD-mcDM1