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ADAT2-siRNA
- Development stage
- Preclinical
- Lead developer
- The Chinese University of Hong Kong
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
ADAT2-siRNA is a small interfering RNA (siRNA) encapsulated in vesicle-like nanoparticles (VNPs) designed to target and knock down adenosine deaminase tRNA-specific 2 (ADAT2). ADAT2 is an enzyme that mediates adenosine-to-inosine (A-to-I) modification at tRNA position 34, which is overexpressed in colorectal cancer (CRC) and promotes oncogenic translation and chemoresistance via the HDAC7-WNT/β-catenin axis. Knockdown of ADAT2 using ADAT2-siRNA promotes dendritic cell migration and maturation, boosts antitumor immunity, and enhances the efficacy of chemotherapy (such as oxaliplatin and 5-fluorouracil) and anti-PD-1 immunotherapy in colorectal cancer models.
- Other names
- VNP-encapsulated ADAT2-siRNAvesicle-like nanoparticle-encapsulated ADAT2-siRNA
02
Targets
CTNNB1 (Beta-catenin)HDAC7
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