Adderall

Adderall is a central nervous system (CNS) stimulant composed of a combination of four amphetamine salts: dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine aspartate monohydrate, and amphetamine sulfate. It is primarily indicated for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. The medication works by increasing the levels of norepinephrine and dopamine in the synaptic cleft through the inhibition of reuptake and the promotion of release via the dopamine transporter (DAT) and norepinephrine transporter (NET). It also acts as an agonist at the trace amine-associated receptor 1 (TAAR1) and inhibits the vesicular monoamine transporter 2 (VMAT2). While widely used as a prescription medication, it was the subject of a Phase 4 clinical trial by the Mayo Clinic (NCT02979327) to evaluate its acute cardiovascular effects, such as changes in blood pressure and heart rate, in healthy adults.

Brand names

AdderallAdderall XRMydayis

Other names

mixed amphetamine saltsMASamphetamine saltsamphetamine + dextroamphetamine