Drug intelligence / Profile preview

adderall xr

Development stage
Approved
Lead developer
Takeda
Modality
Drug Delivery Systems, Small Molecules
Administration
Oral
01

Overview

Adderall XR is a central nervous system (CNS) stimulant medication formulated as an extended-release capsule containing four different amphetamine salts: dextroamphetamine saccharate, dextroamphetamine sulfate, amphetamine aspartate monohydrate, and amphetamine sulfate. It is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in adults and children aged 6 years and older. The drug works primarily by increasing synaptic concentrations of dopamine and norepinephrine through inhibition of their reuptake into presynaptic neurons. This action enhances neurotransmission in brain regions involved in attention and impulse control. Adderall XR provides a double-pulsed delivery system for prolonged therapeutic effect throughout the day[1][2][4][5].

Brand names
Adderall XR
Other names
amphetamine and dextroamphetamine extended-releasemixed amphetamine salts extended-releaseamphetamine salt combo XR
02

Targets

SERT (Sodium-dependent serotonin transporter)TAAR1 (Trace amine-associated receptor 1)DAT (Dopamine plasma membrane transport protein)VMAT2 (Vesicular monoamine transporter 2)MAOA (Monoamine oxidase A)NET (Norepinephrine Transporter)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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