Drug intelligence / Profile preview

adebrelimab + apatinib + paclitaxel (albumin bound)

Development stage
Unknown
Lead developer
Hengrui Pharmaceutical
Modality
Nanoparticles → Drug Delivery Systems, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous, Oral
01

Overview

This is a combination therapy consisting of adebrelimab (an anti-PD-L1 monoclonal antibody), apatinib (a small molecule VEGFR-2 inhibitor), and paclitaxel albumin-bound (a nanoparticle albumin-bound formulation of paclitaxel). Paclitaxel albumin-bound (nab-paclitaxel) is a 130-nm particle formulation that binds paclitaxel to albumin, eliminating the need for solvents like Cremophor EL. This formulation allows for higher doses without increased side effects and improves drug delivery to tumors through albumin-mediated transport mechanisms. Paclitaxel works by preventing the normal breakdown of microtubules during cell division, ultimately causing cancer cell death.

02

Targets

MicrotubuleVEGFR2 (Vascular endothelial growth factor receptor 2)CD274 (Programmed cell death protein 1 ligand 1)

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