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adebrelimab + apatinib + stereotactic body radiotherapy
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
adebrelimab + apatinib + stereotactic body radiotherapy is a combination therapeutic regimen being investigated for the treatment of hepatocellular carcinoma (HCC). The regimen consists of **adebrelimab** (also referred to as adbelimumab or SHR-1316), a humanized IgG4 monoclonal antibody that inhibits the Programmed cell death 1 ligand 1 (PD-L1); **apatinib** (YN968D1), a small molecule tyrosine kinase inhibitor that selectively targets Vascular endothelial growth factor receptor 2 (VEGFR2); and **stereotactic body radiotherapy** (SBRT). This combination is designed to leverage the synergistic effects of immune checkpoint inhibition, anti-angiogenesis, and localized radiation-induced immunogenic cell death. It is currently being evaluated in a Phase II investigator-initiated trial at Fujian Cancer Hospital as a perioperative and conversion therapy to improve surgical resectability and patient outcomes in HCC patients.
- Brand names
- AdelyAiTan
- Other names
- adbelimumabadebrelimabapatinibrivoceranibSHR-1316SHR1316SHR 1316apatinib mesylateSBRTstereotactic body radiotherapy
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)CD274 (Programmed cell death protein 1 ligand 1)
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