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adebrelimab + gemcitabine + oxaliplatin + tyrosine kinase inhibitor
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This is a combination therapy consisting of adebrelimab (a PD-L1 inhibitor), gemcitabine and oxaliplatin (GEMOX chemotherapy regimen), and a tyrosine kinase inhibitor (TKI). The combination is being investigated in open-label, single-arm clinical studies for the first-line treatment of advanced biliary tract cancer. Adebrelimab is a PD-L1 inhibitor that blocks the PD-1/PD-L1 pathway, preventing cancer cells from evading immune detection. GEMOX is a standard chemotherapy combination, while TKIs target specific enzymes involved in cancer cell growth and division.
- Brand names
- Airuika
- Other names
- adebrelimab + GEMOX + TKI
02
Targets
Tyrosine kinaseCD274 (Programmed cell death protein 1 ligand 1)DNA
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