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AdEcSOD-ΔHBD
- Development stage
- Preclinical
- Lead developer
- University of Iowa
- Modality
- Gene Therapies
- Administration
- Intramuscular, Intrathecal, Intratumoral, Intravenous
01
Overview
AdEcSOD-ΔHBD is a replication-deficient adenoviral gene therapy vector that delivers a truncated form of human extracellular superoxide dismutase (EcSOD, or SOD3) lacking the heparin-binding domain (ΔHBD). Unlike wild-type EcSOD, which anchors to cell surfaces and the extracellular matrix via its heparin-binding domain, the truncated EcSOD-ΔHBD protein is secreted and remains in the circulation or extracellular fluid. This allows it to act as a highly efficient soluble scavenger of superoxide radicals. AdEcSOD-ΔHBD has been investigated in preclinical research for its potential to suppress breast cancer metastasis, inhibit pancreatic cancer growth by reducing HIF-1α accumulation, and modulate oxidative stress in cardiovascular and cerebrovascular conditions such as hypertension and subarachnoid hemorrhage.
- Other names
- Ad.ecSOD-ΔHBDAd.ecSODΔHBDAdEC-SODΔHBDAdECSOD-ΔHBDAdECSODΔHBDAdECSOD⌬HBD
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