Adelmidrol

Adelmidrol is a synthetic diethanolamide derivative of azelaic acid and belongs to the ALIAmide (Autacoid Local Injury Antagonist Amides) family, a group of fatty acid derivatives with cannabimimetic properties. It acts primarily as an anti-inflammatory agent by controlling mast cell hyperreactivity and reducing pro-inflammatory pathways such as NF-κB. Its anti-inflammatory effects are mediated in part through activation of peroxisome proliferator-activated receptor gamma (PPARγ), while PPARα does not appear to be involved. Adelmidrol is amphiphilic, allowing for both topical and systemic administration. It has been investigated for use in inflammatory skin disorders (such as atopic dermatitis), chronic inflammation models, osteoarthritis (in combination with hyaluronic acid), interstitial cystitis/bladder pain syndrome (as part of the mixture Vessilen), colitis, arthritis, and other conditions associated with chronic inflammation[1][4][6][7][8].

Brand names

Vessilen

Other names

N,N'-bis(2-hydroxyethyl)nonanediamideAdelMitroladelmidrol [INN]