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adeno-associated viral vector serotype 9 encoding murine hepatocyte growth factor
- Development stage
- Preclinical
- Lead developer
- Universitat Autònoma de Barcelona
- Modality
- Gene Therapies
- Administration
- Parenteral
01
Overview
Adeno-associated viral vector serotype 9 encoding murine hepatocyte growth factor (AAV9-mHGF) is a preclinical gene therapy candidate developed by the Universitat Autònoma de Barcelona (UAB) for the treatment and prevention of type 1 diabetes. The therapy utilizes an adeno-associated virus serotype 9 (AAV9) vector to deliver the murine hepatocyte growth factor (mHGF) gene directly to the pancreas, typically via retrograde pancreatic intraductal injection. Hepatocyte growth factor (HGF) acts as a potent mitogenic and anti-apoptotic factor for pancreatic beta cells. By promoting beta cell replication and survival, AAV9-mHGF aims to preserve beta cell mass, reduce lymphocytic infiltration (insulitis) in the islets of Langerhans, and prevent or reverse autoimmune diabetes.
- Other names
- AAV9-CMV-mHGFAAV-9-CMV-mHGFAAV 9-CMV-mHGFAAV9-mHGFAAV-9-mHGFAAV 9-mHGFadeno-associated viral vector serotype 9 encoding murine hepatocyte growth factor
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