Drug intelligence / Profile preview

adenosine + amiodarone + digoxin + flecainide + procainamide + propranolol

Development stage
Unknown
Lead developer
Assiut University
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

This therapeutic regimen consists of a collection of antiarrhythmic agents evaluated in a clinical audit at Assiut University Children Hospital for the management of supraventricular tachycardia (SVT) in pediatric patients. The regimen includes **adenosine** (an AV nodal blocking agent), **propranolol** (a non-selective beta-blocker), **flecainide** (a Class Ic antiarrhythmic), **amiodarone** (a Class III antiarrhythmic with multi-channel blocking properties), **digoxin** (a cardiac glycoside), and **procainamide** (a Class Ia antiarrhythmic). These drugs are utilized either sequentially or in combination to terminate acute SVT episodes or provide long-term rhythm control, adhering to international guidelines for pediatric cardiology. The audit specifically assesses the efficacy and safety of these established pharmaceuticals in a real-world clinical setting within a pediatric population.

Other names
adenosine, Propranolol, flecainide, amiodarone, propranolol, digoxin and procainamide
02

Targets

ADORA1 (Adenosine receptor A1 subtype)SCN5A (Sodium channel protein type 5 subunit alpha)ADRB1 (β1)KCNH2 (Voltage-gated potassium channel subfamily H member 2)ADRB2 (β2)

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