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adenosine phosphate
- Development stage
- Approved
- Lead developer
- Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
- Modality
- Small Molecules
- Administration
- Intramuscular, Intravenous, Oral
01
Overview
Phosphaden (adenosine phosphate) is an endogenous nucleotide that acts as a vasodilator, antiaggregant, and metabolic regulator. It is a key component of essential coenzymes involved in cellular oxidation-reduction processes and protein synthesis. Phosphaden is used to normalize porphyrin biosynthesis and improve microcirculation. Historically developed and manufactured in Belarus and Russia, it has been indicated for the treatment of acute intermittent porphyria, lead poisoning with polyneuritic syndrome, peripheral vascular diseases (such as obliterating endarteritis and thrombophlebitis), coronary heart disease, and diabetic retinopathy. It functions primarily as an agonist of adenosine receptors and an allosteric activator of AMP-activated protein kinase (AMPK).
- Brand names
- Phosphaden
- Other names
- 5'-adenosine monophosphate5'-adenylate5'-adenylic acid5'-AMPAMPadenosine 5'-(dihydrogen phosphate)adenosine 5'-monophosphateadenosine 5'-monophosphoric acidadenosine 5'-phosphateadenosine 5'-phosphoric acidadenosine monophosphateadenosine-5'-monophosphoric acidadenosine-monophosphateadenosine-phosphateadenosine-phosphoric acidadenylateadenylic acidergadenylic acidmonophosphadeninemuscle adenylic acidmuskeladenylsaeurephosphentaside
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)ADORA2B (Adenosine A2B receptor)ADORA3 (Adenosine A3 receptor)
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