adenoviral HIF-1 construct

The adenoviral HIF-1 construct is a gene therapy agent designed to deliver a constitutively active form of Hypoxia-Inducible Factor 1 (HIF-1) into target cells. In the context of pulmonary hypertension research, it is used to investigate the role of HIF-1 in pulmonary arterial smooth muscle cell (PASMC) proliferation and vascular remodeling. The construct typically utilizes an adenoviral vector to bypass the normal oxygen-dependent degradation of HIF-1α, allowing for sustained activation of downstream signaling pathways, such as the p38-MK2 axis, even under normoxic conditions. This tool helps elucidate mechanisms by which chronic hypoxia leads to medial wall thickening and resistance to apoptosis in pulmonary arteries. Clinically, similar adenoviral HIF-1α constructs have been explored for therapeutic angiogenesis in conditions like peripheral artery disease and myocardial ischemia.

Other names

Ad-HIF-1Ad-HIF1Ad-HIF 1Ad-HIF-1alphaAd-HIF1alphaAd-HIF 1alphaadenoviral HIF-1alpha constructadenoviral constitutively active HIF-1