adenoviral RECK

Adenoviral RECK is a gene therapy construct that utilizes an adenoviral vector to deliver the gene encoding Reversion-inducing cysteine-rich protein with Kazal motifs (RECK). RECK is a membrane-anchored protein that serves as a natural inhibitor of matrix metalloproteinases (MMPs), specifically MMP-2 and MMP-9, which are involved in tissue remodeling and cell migration. By overexpressing RECK, this therapy aims to counteract the downregulation of RECK caused by oxidative stress (such as OxLDL) and inhibit the pathological migration and proliferation of smooth muscle cells. This mechanism suggests potential therapeutic utility in treating vascular proliferative diseases, including atherosclerosis and restenosis, as well as potential applications in oncology where MMP inhibition is relevant.

Other names

adenovirus-mediated RECKAd-RECK gene therapy