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adenovirus-klk1
- Development stage
- Approved
- Lead developer
- Temple University
- Modality
- Gene Therapies
- Administration
- Parenteral
01
Overview
adenovirus-klk1 is an adenoviral-based gene therapy designed to deliver the human tissue kallikrein 1 (KLK1) gene. Developed by researchers at Temple University, it is being investigated for the treatment of systemic lupus erythematosus (SLE) and neuropsychiatric lupus (NPSLE). The mechanism involves the kallikrein-kinin system (KKS), where KLK1 expression leads to the suppression of Type I interferon (IFN) responses, reduction of plasma IFNα levels, and downregulation of interferon-responsive genes. In preclinical models, it has demonstrated the ability to ameliorate kidney pathology and improve depressive-like behaviors associated with lupus.
- Other names
- adenovirus carrying the kallikrein geneadenoviral-mediated KLK1 gene therapy
02
Targets
KNG1 (High-molecular-weight kininogen)
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