adenovirus neutralizing antibody

Adenovirus neutralizing antibody refers to a therapeutic approach utilizing antibodies that bind to and neutralize human adenovirus (HAdV) to prevent viral entry into host cells. In clinical development, particularly by the Guangzhou Women and Children's Medical Center, this specifically refers to the use of **high-titer adenovirus neutralizing antibody plasma**. This plasma-derived biologic is collected from donors with high concentrations of specific neutralizing antibodies and administered via intravenous transfusion to provide passive immunity. The primary indication is severe adenovirus pneumonia in children, where the therapy aims to facilitate viral clearance and reduce in-hospital mortality. The efficacy of this approach is being evaluated in randomized controlled trials comparing high-titer plasma against standard plasma or supportive care.

Other names

adenovirus neutralizing antibody plasmahigh-titer adenovirus neutralizing antibody plasmaadenovirus convalescent plasma