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**Adenovirus type 4 vaccine** is a live, oral vaccine formulated as an enteric-coated tablet. It is typically administered along with a type 7 component in a two-tablet dose and is indicated for active immunization to prevent febrile acute respiratory disease caused by adenovirus type 4 (and type 7) in military populations. The vaccine contains live, non-attenuated adenovirus type 4 that replicates in the intestinal tract, inducing a systemic immune response without causing respiratory illness. It is not available for civilian use, and is primarily intended for military recruits at risk of adenovirus-related outbreaks. The vaccine was developed to replace an earlier adenovirus vaccine discontinued in 1999 and was FDA-approved in 2011. It was developed and manufactured under contract to the U.S. Army[1][2][3][5][8][9].
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