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ADGN-120

Development stage: Preclinical
Lead developer: DIVINCELL
Modality: RNA Therapeutics → Nucleic Acid Therapeutics, Peptides

Overview

ADGN-120 is a synthetic peptide therapeutic in preclinical development for the treatment of cancers driven by KRAS mutations. It acts as an inhibitor targeting multiple mutant forms of the KRAS protein, specifically KRAS G12C, G12D, and G12V. The drug is designed to modulate KRAS protein expression using peptide-based guide RNA (gRNA) technology. Initially developed by DIVINCELL SAS and also associated with Aanastra (formerly Aadigen), its primary indication is for neoplasms harboring relevant KRAS mutations[1][2][3].

Targets

KRASG12V (KRAS G12V)KRASG12C (Kirsten rat sarcoma viral oncogene homolog G12C)KRASG12D (Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutant)

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